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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CREBBP All Species: 33.64
Human Site: S2421 Identified Species: 61.67
UniProt: Q92793 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q92793 NP_001073315.1 2442 265351 S2421 T P S R S A L S S E L S L V G
Chimpanzee Pan troglodytes XP_523285 2442 265358 S2421 T P S R S A L S S E L S L V G
Rhesus Macaque Macaca mulatta XP_001095225 2442 265320 S2421 T P S R S A L S S E L S L V G
Dog Lupus familis XP_851777 2404 260682 S2383 T P N R S A L S S E L S L V G
Cat Felis silvestris
Mouse Mus musculus P45481 2441 265456 S2420 T P N R S A L S S E L S L V G
Rat Rattus norvegicus NP_596872 2444 265618 S2423 T P N R S A L S S E L S L V G
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_414964 2447 266615 S2426 T P N R S A L S N E L S L V G
Frog Xenopus laevis NP_001088637 2428 264402 T2407 P P N R S A L T N D L S L V G
Zebra Danio Brachydanio rerio NP_001082924 2111 234059 S2091 P N R G G L P S D L N M V G D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_524642 3276 340709 G3245 V G V G V G V G V N V N V G N
Honey Bee Apis mellifera XP_001122031 2606 284119 T2585 A P P P T S G T D S S E V T P
Nematode Worm Caenorhab. elegans P34545 2056 227161 L2036 R I D C P R F L Y F P F F L N
Sea Urchin Strong. purpuratus XP_782558 2635 288594 K2597 T P M G H S N K N S L Q S P A
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.9 99.4 93.9 N.A. 94.8 95.8 N.A. N.A. 88 76 61.5 N.A. 36.5 42.7 30.5 38.5
Protein Similarity: 100 99.9 99.6 95.5 N.A. 96.4 97.2 N.A. N.A. 92 83.3 68.8 N.A. 46.7 54.7 43.9 50.9
P-Site Identity: 100 100 100 93.3 N.A. 93.3 93.3 N.A. N.A. 86.6 66.6 6.6 N.A. 0 6.6 0 20
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. N.A. 100 93.3 13.3 N.A. 26.6 33.3 6.6 33.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 0 0 0 62 0 0 0 0 0 0 0 0 8 % A
% Cys: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 8 0 0 0 0 0 16 8 0 0 0 0 8 % D
% Glu: 0 0 0 0 0 0 0 0 0 54 0 8 0 0 0 % E
% Phe: 0 0 0 0 0 0 8 0 0 8 0 8 8 0 0 % F
% Gly: 0 8 0 24 8 8 8 8 0 0 0 0 0 16 62 % G
% His: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 0 0 8 62 8 0 8 70 0 62 8 0 % L
% Met: 0 0 8 0 0 0 0 0 0 0 0 8 0 0 0 % M
% Asn: 0 8 39 0 0 0 8 0 24 8 8 8 0 0 16 % N
% Pro: 16 77 8 8 8 0 8 0 0 0 8 0 0 8 8 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % Q
% Arg: 8 0 8 62 0 8 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 24 0 62 16 0 62 47 16 8 62 8 0 0 % S
% Thr: 62 0 0 0 8 0 0 16 0 0 0 0 0 8 0 % T
% Val: 8 0 8 0 8 0 8 0 8 0 8 0 24 62 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _